After losing the love of his life, 4th wall-breaking mercenary Wade Wilson aka Deadpool (Ryan Reynolds) must protect Russel (Julian Dennison) must assemble a team of mutants and protect Russel from Cable (Josh Brolin), a no-nonsense, dangerous cyborg from the future and Deadpool must learn the most important lesson of all, to be part of a family again.

This is the origin story of former Special Forces operative turned mercenary Wade Wilson, who after being subjected to a rogue experiment that leaves him with accelerated healing powers, adopts the alter ego Deadpool. Armed with his new abilities and a dark, twisted sense of humor, Deadpool hunts down the man who nearly destroyed his life.